Because of genome sequencing technology, we have arrived at a remarkable time in biology. At last we can see the source code for life: the complete genomic DNA sequences that specify development, regulation, and function of organisms. But we still don't really understand how to read this trove of encoded information, and we don't really understand in any satisfying detail how it evolved.
Our laboratory develops computational methods for genome sequence analysis. We are particularly interested in methods for identifying remote evolutionary relationships between distantly related protein and RNA sequences.
We're a Howard Hughes Medical Institute laboratory at Harvard University, in the Molecular & Cellular Biology Department, with affiliations to Applied Mathematics, to the FAS Center for Systems Biology, and to the Center for Brain Science.